2021年氫健康產(chǎn)業(yè)專家及論文匯總(氫氣醫(yī)學臨床文獻匯總) 1. Huang KC, Yang CC, Lee KT, Chien CT. Reduced hemodialysis-induced oxidative stress in end-stage renal disease patients by electrolyzed reduced water. Kidney Int. 2003;64(2):704–14. 早期含氫氣電解水的臨床研究，尿毒癥 2. Kajiyama S, Hasegawa G, Asano M, Hosoda H, Fukui M, Nakamura N, et al. Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance. Nutr Res. 2008;28(3):137–43氫水治療糖尿病。 3. Nakayama M, Kabayama S, Nakano H, Zhu WJ, Terawaki H, Nakayama K, et al. Biological effects of electrolyzed water in hemodialysis. Nephron Clin Pract. 2009;112(1):c9–15. 電解水透析液 4. Nakao A, Toyoda Y, Sharma P, Evans M, Guthrie N. Effectiveness of hydrogen rich water on antioxidant status of subjects with potential metabolic syndrome-an open label pilot study. J Clin Biochem Nutr. 2010;46(2):140–9. 氫水治療代謝綜合征 
5. Nakayama M, Nakano H, Hamada H, Itami N, Nakazawa R, Ito S. A novel bioactive haemodialysis system using dissolved dihydrogen (H2) produced by water electrolysis: a clinical trial. Nephrol Dial Transplant. 2010;25(9):3026–33. 氫水透析 6. Ono H, Nishijima Y, Adachi N, Tachibana S, Chitoku S, Mukaihara S, et al. Improved brain MRI indices in the acute brain stem infarct sites treated with hydroxyl radical scavengers, Edaravone and hydrogen, as compared to Edaravone alone. A non-controlled study. Med Gas Res. 2011;1(1):12. 氫氣和依達拉奉對比治療腦干缺血。 7. Ito M, Ibi T, Sahashi K, Ichihara M, Ito M, Ohno K. Open-label trial and randomized, double-blind, placebo-controlled, crossover trial of hydrogen-enriched water for mitochondrial and inflammatory myopathies. Med Gas Res. 2011;1(1):24. 線粒體和炎癥肌肉病 8. Kang KM, Kang YN, Choi IB, Gu Y, Kawamura T, Toyoda Y, et al. Effects of drinking hydrogen-rich water on the quality of life of patients treated with radiotherapy for liver tumors. Med Gas Res. 2011;1(1):11. 放射治療后生活質(zhì)量下降 9. Ono H, Nishijima Y, Adachi N, Sakamoto M, Kudo Y, Nakazawa J, et al. Hydrogen(H2) treatment for acute erythymatous skin diseases. A report of 4 patients with safety data and a non-controlled feasibility study with H2 concentration measurement on two volunteers. Med Gas Res. 2012;2(1):14. 4例急性皮膚病 10. Ostojic SM. Serum alkalinization and hydrogen-rich water in healthy men. Mayo Clin Proc. 2012;87(5):501–2. 氫水對運動后血液酸化 11. Ishibashi T, Sato B, Rikitake M, Seo T, Kurokawa R, Hara Y, et al. Consumption of water containing a high concentration of molecular hydrogen reduces oxidative stress and disease activity in patients with rheumatoid arthritis: an open-label pilot study. Med Gas Res. 2012;2(1):27. 高濃度氫水對類風濕關(guān)節(jié)炎的治療 
12. Shimouchi A, Nose K, Shirai M, Kondo T. Estimation of molecular hydrogen consumption in the human whole body after the ingestion of hydrogen-rich water. Adv Exp Med Biol. 2012;737:245–50. 氫水飲用后人體氫氣消耗情況分析 13. Ono H, Nishijima Y, Adachi N, Sakamoto M, Kudo Y, Kaneko K, et al. A basic study on molecular hydrogen (H2) inhalation in acute cerebral ischemia patients for safety check with physiological parameters and measurement of blood H2 level. Med Gas Res. 2012;2(1):21. 氫氣吸入對急性腦缺血患者的安全性研究 14. Aoki K, Nakao A, Adachi T, Matsui Y, Miyakawa S. Pilot study: Effects of drinking hydrogen-rich water on muscle fatigue caused by acute exercise in elite athletes. Med Gas Res. 2012;2(1):12. 氫水對急性運動后肌肉疲勞 15. Song G, Li M, Sang H, Zhang L, Li X, Yao S, et al. Hydrogen-rich water decreases serum LDL-cholesterol levels and improves HDL function in patients with potential metabolic syndrome. J Lipid Res. 2013;54(7):1884–93. 氫水對血液低密度脂蛋白膽固醇水平的影響 16. Shimouchi A, Nose K, Mizukami T, Che DC, Shirai M. Molecular hydrogen consumption in the human body during the inhalation of hydrogen gas. Adv Exp Med Biol. 2013;789:315–21. 氫氣吸入后人體消耗氫氣的研究 
17. Yoritaka A, Takanashi M, Hirayama M, Nakahara T, Ohta S, Hattori N. Pilot study of H(2) therapy in Parkinson’s disease: a randomized double-blind placebo-controlled trial. Mov Disord. 2013;28(6):836–9. 氫水飲用治療帕金森病雙盲安慰劑對照試驗。 18. Nagatani K, Nawashiro H, Takeuchi S, Tomura S, Otani N, Osada H, et al. Safety of intravenous administration of hydrogen-enriched fluid in patients with acute cerebral ischemia: initial clinical studies. Med Gas Res. 2013;3(1):13. 靜脈注射氫氣鹽水對急性腦缺血后治療的安全性評價。 19. Li Q, Kato S, Matsuoka D, et al. Hydrogen water intake via tube-feeding for patients with pressure ulcer and its reconstructive effects on normal human skin cells in vitro.[J]. Medical Gas Research, 2013. 3(1):20-20. 氫水灌胃對褥瘡治療效果的評價 20. Xia C, Liu W, Zeng D, Zhu L, Sun X, Sun X. Effect of hydrogen-rich water on oxidative stress, liver function, and viral load in patients with chronic hepatitis B. Clin Transl Sci. 2013;6(5):372–5. 氫水對人類慢性肝炎的治療 21. Tsumoto S, Ueda T, Kakizaki H. Effect of supplementation with hydrogen-rich water in patients with interstitial cystitis/painful bladder syndrome. Urology. 2013;81(2):226–30. 氫水對間質(zhì)膀胱炎治療，緩解疼痛! 
22. Terawaki H, Hayashi Y, Zhu WJ, Matsuyama Y, Terada T, Kabayama S, et al. Transperitoneal administration of dissolved hydrogen for peritoneal dialysis patients: a novel approach to suppress oxidative stress in the peritoneal cavity. Med Gas Res. 2013;3(1):14. 氫氣溶解在透析液，尿毒癥腹膜透析后氧化應(yīng)激。 23. Lucas K, Maes M. Molecular mechanisms underpinning laser printer and photocopier induced symptoms, including chronic fatigue syndrome and respiratory tract hyperresponsiveness: pharmacological treatment with cinnamon and hydrogen. Neuro Endocrinol Lett. 2013;34(8):723-37. PMID: 24522022. 慢性疲勞綜合征個案，德國教授作者自己是受試者。 24. Takeuchi S, Mori K, Arimoto H, Fujii K, Nagatani K, Tomura S, et al. Effects of intravenous infusion of hydrogen-rich fluid combined with intra-cisternal infusion of magnesium sulfate in severe aneurysmal subarachnoid hemorrhage: study protocol for a randomized controlled trial. BMC Neurol. 2014;14:176. 隨機對照試驗研究氫水對嚴重血管瘤破裂蛛網(wǎng)膜下腦出血的治療研究。 25. Terawaki H, Zhu WJ, Matsuyama Y, Terada T, Takahashi Y, Sakurai K, et al. Effect of a hydrogen (H2)-enriched solution on the albumin redox of hemodialysis patients. Hemodial Int. 2014;18(2):459–66. 氫氣溶解血液透析液對白蛋白氧化還原修飾的作用。 26. Sakai T, Sato B, Hara K, Hara Y, Naritomi Y, Koyanagi S, et al. Consumption of water containing over 3.5 mg of dissolved hydrogen could improve vascular endothelial function. Vasc Health Risk Manag. 2014;10:591–7. 高濃度氫水改善健康人血管內(nèi)皮細胞功能的研究。 27. Ostojic SM, Stojanovic MD. Hydrogen-rich water affected blood alkalinity in physically active men. Res Sports Med. 2014;22(1):49–60. 氫水對運動后血液酸化的研究 
28. Ostojic SM, Vukomanovic B, Calleja-Gonzalez J, Hoffman JR. Effectiveness of oral and topical hydrogen for sports-related soft tissue injuries. Postgrad Med. 2014;126(5):187–95. 口服氫片對運動后軟組織損傷的改善作用。 29. Ishibashi T, Sato B, Shibata S, Sakai T, Hara Y, Naritomi Y, et al. Therapeutic efficacy of infused molecular hydrogen in saline on rheumatoid arthritis: a randomized, double-blind, placebo-controlled pilot study. Int Immunopharmacol. 2014;21(2):468–73. 雙盲安慰劑對照試驗證明氫氣鹽水對類風濕關(guān)節(jié)炎的治療作用。 30. Tanikawa R, Takahashi I, Okubo N, Ono M, Okumura T, Ishibashi G, et al. Relationship between Exhaled Hydrogen and Human Neutrophil Function in the Japanese General Population. Hirosaki Medical Journal. 2015;65:138–46 氫氣水平和人類中性顆粒細胞功能的關(guān)系研究。 31. Tamasawa A, Mochizuki K, Hariya N, et al. Hydrogen gas production is associated withreduced interleukin-1β mRNA in peripheral blood after a single dose of acarbosein Japanese type 2 diabetic patients.[J]. European Journal of Pharmacology,2015. 762:96-101 單次口服阿卡波糖促進腸道產(chǎn)生氫氣對二型糖尿病外周血炎癥反應(yīng)的作用。 32. Terawaki H, Nakano H, Zhu WJ, Nakayama M. Successful treatment of encapsulating peritoneal sclerosis by hemodialysis and peritoneal lavage using dialysate containing dissolved hydrogen. Perit Dial Int. 2015;35(1):107–12. 氫溶解透析液對腹膜硬化的治療作用。 33. Nakata K, Yamashita N, Noda Y, Ohsawa I. Stimulation of human damaged sperm motility with hydrogen molecule. Med Gas Res. 2015;5(1):2. 氫氣對人類精子運動能力的作用。 34. Ishibashi T, Ichikawa M, Sato B, Shibata S, Hara Y, Naritomi Y, et al. Improvement of psoriasis-associated arthritis and skin lesions by treatment with molecular hydrogen: A report of three cases. Mol Med Rep. 2015;12(2):2757–64. 氫氣對銀屑病相關(guān)關(guān)節(jié)炎和皮膚損傷的治療作用。 35. Song G, Lin Q, Zhao H, Liu M, Ye F, Sun Y, et al. Hydrogen activates ATP-binding cassette transporter A1-dependent efflux ex vivo and improves high-density lipoprotein function in patients with hypercholesterolemia: a double-blinded, randomized and placebo-controlled trial. J Clin Endocrinol Metab. 2015;100:2724–33. 雙盲安慰劑對照試驗 氫氣改善高密度脂蛋白功能的臨床試驗。 36. Tange Y, Takesawa S, Yoshitake S. Dialysate with high dissolved hydrogen facilitates dissociation of indoxyl sulfate from albumin. Nephrourol Mon. 2015;7(2):e26847. 氫氣透析對血液白蛋白的保護作用。 37. Azuma T, Yamane M, Ekuni D, Kawabata Y, Kataoka K, Kasuyama K, Maruyama T, Tomofuji T, Morita M. Drinking Hydrogen-Rich Water Has Additive Effects on Non-Surgical Periodontal Treatment of Improving Periodontitis: A Pilot Study. Antioxidants (Basel). 2015 Jul 9;4(3):513-22. 氫水作為輔助治療牙周炎 38. Igarashi T, Ohsawa I, Kobayashi M, Igarashi T, Suzuki H, Iketani M, Takahashi H. Hydrogen prevents corneal endothelial damage in phacoemulsification cataract surgery. Sci Rep. 2016 Aug 8;6:31190. 氫氣對手術(shù)過程的眼角膜內(nèi)皮細胞損傷保護作用。 39. Qian LR, Shen JL. Successful treatment with hydrogen rich water in a case of chronic graft-versus-host-disease. Med Gas Res. 2016 Oct 14;6(3):177-179. 氫水對移植物抗宿主病的個案報道 
40. Tamura T, Hayashida K, Sano M et al. Feasibility and safety of hydrogen gas inhalationfor post-cardiac arrest syndrome - first-in-human pilot study. Circ. J. 2016;80: 1870–3 氫氣在心臟驟停綜合征患者的安全性研究 41. Yoritaka A, Abe T, Ohtsuka C, Maeda T, Hirayama M, Watanabe H, Saiki H, Oyama G, Fukae J, Shimo Y, Hatano T, Kawajiri S, Okuma Y, Machida Y, Miwa H, Suzuki C, Kazama A, Tomiyama M, Kihara T, Hirasawa M, Shimura H, Hattori N. A randomized double-blind multi-center trial of hydrogen water for Parkinson's disease: protocol and baseline characteristics. BMC Neurol. 2016 May 12;16:66. 氫水對帕金森病治療的多中性研究方案。 42. Katsumata Y, Sano F, Abe T, et al. The Effects of Hydrogen Gas Inhalation on Adverse Left Ventricular Remodeling After Percutaneous Coronary Intervention for ST-Elevated Myocardial Infarction-First Pilot Study in Humans[J]. Circulation Journal,2017. 81(7):940-947. 氫氣吸入對心肌梗塞介入手術(shù)后心臟保護作用。 43. Korovljev D, Trivic T, Drid P, et al. Molecular hydrogen affects body composition,metabolic profiles, and mitochondrial function in middle-aged overweight women[J]. Irish Journal of Medical Science, 2017:1-5.氫氣對超重女性代謝和線粒體功能的影響 44. Mizuno K, Sasaki A, Ebisu K, et al. Hydrogen-rich water for improvements of mood,anxiety, and autonomic nerve function in daily life[J]. Medical Gas Research,2017. 7(4):247. 氫水改善焦慮和自主神經(jīng)功能 45. Tamura T, Hayashida K, Sano M, Onuki S, Suzuki M. Efficacy of inhaled HYdrogen on neurological outcome following BRain Ischemia During post-cardiac arrest care (HYBRID II trial): study protocol for a randomized controlled trial. Trials. 2017 Oct 23;18(1):488. 臨床研究方案 46. Nakayama M, Itami N, Suzuki H, Hamada H, Osaka N, Yamamoto R, Tsunoda K, Nakano H, Watanabe K, Zhu WJ, Maruyama Y, Terawaki H, Kabayama S, Nakazawa R, Miyazaki M, Ito S. Possible clinical effects of molecular hydrogen (H2) delivery during hemodialysis in chronic dialysis patients: Interim analysis in a 12 month observation. PLoS One. 2017 Sep 13;12(9):e0184535. 氫氣作為慢性透析病人的作用 47. Nakayama M, Zhu WJ, Watanabe K, Gibo A, Sherif AM, Kabayama S, Ito S. Dissolved molecular hydrogen (H2) in Peritoneal Dialysis (PD) solutions preserves mesothelial cells and peritoneal membrane integrity. BMC Nephrol. 2017 Oct 31;18(1):327. 氫氣對腹透患者腹膜完整性的作用。 48. Yang Q, Ji G, Pan R, Zhao Y, Yan P. Protective effect of hydrogen-rich water on liver function of colorectal cancer patients treated with mFOLFOX6 chemotherapy. Mol Clin Oncol. 2017 Nov;7(5):891-896. 氫水對化療后肝臟功能的保護研究 49. Ono H, Nishijima Y, Ohta S, et al. Hydrogen Gas Inhalation Treatment in Acute Cerebral Infarction: A Randomized Controlled Clinical Study on Safety and Neuroprotection.[J]. Journal of Stroke & Cerebrovascular Diseases, 2017. 氫氣吸入對急性腦缺血的臨床研究。 50. Nishimaki K, Asada T, Ohsawa I, Nakajima E, Ikejima C, Yokota T, Kamimura N, Ohta S. Effects of Molecular Hydrogen Assessed by an Animal Model and a Randomized Clinical Study on Mild Cognitive Impairment. Curr Alzheimer Res. 2018 Mar 14;15(5):482-492. 氫氣對慢性認知障礙的隨機臨床試驗 51. Nakayama M, Itami N, Suzuki H, Hamada H, Yamamoto R, Tsunoda K, Osaka N, Nakano H, Maruyama Y, Kabayama S, Nakazawa R, Miyazaki M, Ito S. Novel haemodialysis (HD) treatment employing molecular hydrogen (H2)-enriched dialysis solution improves prognosis of chronic dialysis patients: A prospective observational study. Sci Rep. 2018 Jan 10;8(1):254. 氫氣溶解透析液對尿毒癥透析改善作用 
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