太田成男（Shigeo Ohta），日本醫(yī)科大學(xué)老年病研究所首席教授，1951年生于日本福島縣。1974年畢業(yè)于東京大學(xué)理學(xué)部。1979年完成東京大學(xué)研究生部藥學(xué)系研究科博士課程后，歷任瑞士巴塞爾大學(xué)生命中心研究所研究員，自治醫(yī)科大學(xué)講師、副教授，自1994年起任現(xiàn)職。他從30余年的研究中發(fā)現(xiàn)，線粒體所具有的機(jī)能，和人的身心健康密切相關(guān)。他是日本線粒體研究最著名的科學(xué)家第。先后擔(dān)任日本線粒體學(xué)會(huì)理事長(zhǎng)、日本Cell Death學(xué)會(huì)理事長(zhǎng)、氫分子生物醫(yī)學(xué)研究會(huì)理事長(zhǎng)等職務(wù)。著有與作家瀨名秀明氏合著的《與線粒體共存》（角川書店）、《線粒體的威力》（新潮社）等多部著作。
在氫氣生物學(xué)效應(yīng)領(lǐng)域，太田教授于2007年7月在國(guó)際著名醫(yī)學(xué)雜志《自然醫(yī)學(xué)》上發(fā)表第一篇關(guān)于少量氫氣治療疾病的研究，提出氫氣選擇性抗氧化的新概念，啟動(dòng)了氫氣治療疾病的國(guó)際研究熱潮。該文章發(fā)表以來，引起國(guó)際學(xué)術(shù)界的極大關(guān)注，目前已經(jīng)被引用450多次，來自日本、中國(guó)和美國(guó)等國(guó)家的眾多學(xué)者圍繞呼吸氫氣、飲用氫氣水和注射氫氣鹽水等對(duì)各類疾病治療效果的評(píng)價(jià)進(jìn)行了廣泛研究，已經(jīng)先后用動(dòng)物試驗(yàn)研究證明氫氣對(duì)80多種重要疾病具有治療作用。太田教授聯(lián)合美國(guó)的張和教授、Nakao教授和中國(guó)的孫學(xué)軍教授于2011年5月創(chuàng)辦《醫(yī)學(xué)氣體研究》雜志，目前已經(jīng)成為氫氣生物醫(yī)學(xué)研究學(xué)術(shù)論文發(fā)表的最主要期刊。
太田教授是氫氣生物學(xué)的奠基人，不僅提出了氫氣治療疾病的選擇性抗氧化理論，而且率先在國(guó)際上證明氫氣對(duì)腦缺血、肝臟缺血、心肌缺血、肥胖、巴金森病具有治療作用，積極和企業(yè)合作開發(fā)氫氣水等相關(guān)產(chǎn)品，并在企業(yè)贊助下建立國(guó)際上第一個(gè)專門研究氫氣生物學(xué)效應(yīng)的氫氣醫(yī)學(xué)研究中心，而且他自己熱心幫助和指導(dǎo)年輕學(xué)者開展氫氣生物學(xué)研究，也積極開發(fā)相關(guān)氫氣相關(guān)產(chǎn)品，大力推動(dòng)日本氫氣臨床轉(zhuǎn)化醫(yī)學(xué)研究，撰寫多部健康有關(guān)科譜書籍，對(duì)日本和國(guó)際氫氣生物醫(yī)學(xué)的發(fā)展作出了不可替代的作用。
太田發(fā)表的氫氣生物學(xué)論文17篇
1. Ohsawa, Ikuroh,Masahiro Ishikawa, Kumiko Takahashi, Megumi Watanabe, Kiyomi Nishimaki, KumiYamagata, Ken-ichiro Katsura, Yasuo Katayama, Sadamitsu Asoh, and Shigeo Ohta."Hydrogen acts as a therapeutic antioxidant by selectively reducingcytotoxic oxygen radicals." Nature medicine 13, no. 6 (2007):688-694.
2. Fukuda, Kei-ichi,Sadamitsu Asoh, Masahiro Ishikawa, Yasuhiro Yamamoto, Ikuroh Ohsawa, and ShigeoOhta. "Inhalation of hydrogen gas suppresses hepatic injury caused byischemia/reperfusion through reducing oxidative stress." Biochemicaland Biophysical Research Communications 361, no. 3 (2007): 670-674.
3. Hayashida,Kentaro, Motoaki Sano, Ikuroh Ohsawa, Ken Shinmura, Kayoko Tamaki, KensukeKimura, Jin Endo et al. "Inhalation of hydrogen gas reduces infarct sizein the rat model of myocardial ischemia–reperfusion injury." Biochemicaland biophysical research communications 373, no. 1 (2008): 30-35.
4. Cai, Jianmei,Zhimin Kang, Wen Wu Liu, Xu Luo, Sun Qiang, John H. Zhang, Shigeo Ohta et al."Hydrogen therapy reduces apoptosis in neonatal hypoxia–ischemia ratmodel." Neuroscience letters 441, no. 2 (2008): 167-172.
5. Nagata, Kazufumi,Naomi Nakashima-Kamimura, Toshio Mikami, Ikuroh Ohsawa, and Shigeo Ohta."Consumption of molecular hydrogen prevents the stress-induced impairmentsin hippocampus-dependent learning tasks during chronic physical restraint inmice." Neuropsychopharmacology 34, no. 2 (2008): 501-508.
6. Ohsawa, Ikuroh,Kiyomi Nishimaki, Kumi Yamagata, Masahiro Ishikawa, and Shigeo Ohta."Consumption of hydrogen water prevents atherosclerosis in apolipoproteinE knockout mice." Biochemical and biophysical research communications377, no. 4 (2008): 1195-1198.
7. Sato, Yasunori,Shizuo Kajiyama, Akiko Amano, Yoshitaka Kondo, Toru Sasaki, Setsuko Handa,Ryoya Takahashi et al. "Hydrogen-rich pure water prevents superoxideformation in brain slices of vitamin C-depleted SMP30/GNL knockout mice."Biochemicaland biophysical research communications 375, no. 3 (2008): 346-350.
8. Fu, Yuan, MikakoIto, Yasunori Fujita, Masafumi Ito, Masatoshi Ichihara, Akio Masuda, YumiSuzuki et al. "Molecular hydrogen is protective against6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson'sdisease." Neuroscience Letters 453, no. 2 (2009): 81-85.
9. Nakashima-Kamimura,Naomi, Takashi Mori, Ikuroh Ohsawa, Sadamitsu Asoh, and Shigeo Ohta."Molecular hydrogen alleviates nephrotoxicity induced by an anti-cancerdrug cisplatin without compromising anti-tumor activity in mice." Cancerchemotherapy and pharmacology 64, no. 4 (2009): 753-761.
10. Oharazawa,Hideaki, Tsutomu Igarashi, Takashi Yokota, Hiroaki Fujii, Hisaharu Suzuki,Mitsuru Machide, Hiroshi Takahashi, Shigeo Ohta, and Ikuroh Ohsawa. "Protectionof the retina by rapid diffusion of hydrogen: administration of hydrogen-loadedeye drops in retinal ischemia–reperfusion injury." Investigativeophthalmology & visual science 51, no. 1 (2010): 487-492.
11. Ohta, Shigeo,Atsunori Nakao, and Kinji Ohno. "The 2011 medical molecular hydrogensymposium: an inaugural symposium of the journal medical Gas research." MedGas Res 1, no. 1 (2011): 10.
12. Hanaoka, Teruyasu,Naomi Kamimura, Takashi Yokota, Shinro Takai, and Shigeo Ohta. "Molecularhydrogen protects chondrocytes from oxidative stress and indirectly alters geneexpressions through reducing peroxynitrite derived from nitric oxide."Medicalgas research 1, no. 1 (2011): 18.
13. Kamimura, Naomi,Kiyomi Nishimaki, Ikuroh Ohsawa, and Shigeo Ohta. "Molecular hydrogenimproves obesity and diabetes by inducing hepatic FGF21 and stimulating energymetabolism in db/db mice." Obesity 19, no. 7 (2011): 1396-1403.
14. Terasaki,Yasuhiro, Ikuroh Ohsawa, Mika Terasaki, Mikiko Takahashi, Shinobu Kunugi, KangDedong, Hirokazu Urushiyama et al. "Hydrogen therapy attenuatesirradiation-induced lung damage by reducing oxidative stress." AmericanJournal of Physiology-Lung Cellular and Molecular Physiology 301, no. 4(2011): L415-L426.
15. Ohta, Shigeo."Molecular hydrogen is a novel antioxidant to efficiently reduce oxidativestress with potential for the improvement of mitochondrial diseases." Biochimicaet Biophysica Acta (BBA)-General Subjects 1820, no. 5 (2012): 586-594.
16. Hayashida, Kei,Motoaki Sano, Naomi Kamimura, Takashi Yokota, Masaru Suzuki, Yuichiro Maekawa,Akio Kawamura et al. "H2 Gas Improves Functional Outcome After CardiacArrest to an Extent Comparable to Therapeutic Hypothermia in a Rat Model."Journal of the American Heart Association 1, no. 5 (2012).
17. Yoritaka, Asako,Masashi Takanashi, Masaaki Hirayama, Toshiki Nakahara, Shigeo Ohta, andNobutaka Hattori. "Pilot study of H2 therapy in Parkinson's disease: Arandomized double‐blind placebo‐controlled trial." MovementDisorders (2013). |
